FCHo2, instead of talin, enables inside-out activation of integrin αvβ5 in curved adhesions
Chih‐Hao Lu, Christina E. Lee, Wei Zhang, Yang� Yang, Luis A. Valencia, He You, Ching‐Ting Tsai, Bianxiao Cui
This paper identifies FCHo2 as a curvature-sensing protein that enables inside-out activation of integrin αvβ5 in curved adhesions, distinct from talin's role in focal adhesions.
bioRxiv · Nov 28, 2025 · PreprintCell Biology