Bianxiao Cui

Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces

This study shows CD16a mediates NK cell activation by transducing piconewton forces, integrating biochemical and biophysical signals to enhance ADCC.

Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival

This study identifies membrane curvature as a mechanism for Src kinase activation in detached cancer cells, showing that disrupting this process inhibits metastatic survival.

FCHo2, instead of talin, enables inside-out activation of integrin αvβ5 in curved adhesions

This paper identifies FCHo2 as a curvature-sensing protein that enables inside-out activation of integrin αvβ5 in curved adhesions, distinct from talin's role in focal adhesions.

Assembloid model to study loop circuits of the human nervous system

The paper develops an assembloid model of the human cortico-striatal-thalamic-cortical circuit to study its function and disease-related disruptions.

Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

This study shows PM curvature promotes ER-PM contact formation in cardiomyocytes via junctophilin-EHD interactions.

Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids

This paper introduces kirigami electronics for long-term, minimally-invasive electrophysiological recording of human neural organoids and assembloids in suspension.

Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids

This paper introduces a stretchable mesh electrode system for long-term electrical interfacing with human cortical organoids, demonstrating stable performance and successful integration with neural tissue.

Light-inducible Deformation of Mitochondria in Live Cells

This paper introduces an optogenetic method to deform mitochondria in live cells using light to recruit molecular motors, enabling precise mechano-stimulation and study of mitochondrial mechanics and function.

Label-free optical detection of bioelectric potentials using electrochromic thin films

This paper introduces ECORE, a label-free optical method for recording neuroelectric activities without photobleaching or phototoxicity, demonstrating its use in various cell types and brain slices.

Construction of light-activated neurotrophin receptors using the improved Light-Induced Dimerizer (iLID)

This paper constructs light-activated neurotrophin receptors using the iLID system and demonstrates their ability to reproduce downstream signaling in response to blue light.

Light-inducible generation of membrane curvature in live cells with engineered BAR domain proteins

This paper develops optogenetic systems to precisely control nanoscale membrane curvature in live cells using engineered BAR domain proteins.

Optical activation of TrkB receptors

This paper develops optogenetic methods to activate TrkB receptors with spatial and temporal control, finding that the CRY2-based approach is most efficient.

Optical activation of TrkA signaling

This paper develops light-inducible methods to activate TrkA signaling without NGF, enabling precise spatial and temporal control of neuronal signaling pathways.

Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception

This study investigates the NGFR100W mutation in NGF, showing it supports neuronal survival via TrkA but fails to activate p75NTR, distinguishing trophic from nociceptive signaling.