Engineering programmable CAR-T cells with tunable controls as fail-safe mechanisms during cancer immunotherapy
Mikail Dogan, Lina Kozhaya, Lindsey Placek, Ece Karhan, Mesut Yiğit, Christina Mohammed, Qi Zhao, Derya Unutmaz
This study develops a synthetic biology toolbox to engineer CAR-T cells with tunable controls, enabling safe and effective cancer immunotherapy through fail-safe mechanisms.
bioRxiv · Jul 9, 2024 · PreprintImmunology