Author

Christina Sharkey

Beth Israel Deaconess Medical CenterPrimary ORCID profile (0000-0002-2449-2148 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Christina SharkeyiD1 paper · Beth Israel Deaconess Medical Center

Biology Disciplines

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Pathology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Organism:mouse· 1

Frequent Co-Authors

Aria F. OlumiiD· 2 shared Boqing GuiD· 2 shared Xingbo LongiD· 2 shared Yaoliang TangiD· 2 shared Zongwei WangiD· 2 shared Aaron FleishmaniD· 1 shared Boris GershmaniD· 1 shared Heidi J. RayalaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPathology

Aria F. OlumiORCID

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2 papers

Recent·Most cited

Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia

Christina Sharkey, Boqing Gu, Xingbo Long, Yaoliang Tang, Nicolas Patsatzis, Steven Li, Aria F. Olumi, Zongwei Wang

This study shows SRD5A2 promotes prostate growth via WNT5A-LEF1-IGF1 signaling in BPH, independent of androgen levels.

American Journal Of Pathology · Sep 13, 2025Peer-reviewedPathology

Stem-like Prostate Remodeling in Obesity Mediates Resistance to 5α-Reductase Inhibition Therapy in BPH

Xingbo Long, Christina Sharkey, Rongbin Ge, Shuoshuo Wang, Yaoliang Tang, Aaron Fleishman, Boqing Gu, Ruslan Korets, Boris Gershman, Heidi J. Rayala, Zongwei Wang, Aria F. Olumi

This study shows that obesity-induced stem-like prostate remodeling reduces 5α-reductase inhibitor effectiveness in BPH, and combining weight control with therapy improves outcomes.

bioRxiv · Sep 8, 2025 · PreprintPathology