Stem-like Prostate Remodeling in Obesity Mediates Resistance to 5α-Reductase Inhibition Therapy in BPH
Xingbo Long, Christina Sharkey, Rongbin Ge, Shuoshuo Wang, Yaoliang Tang, Aaron Fleishman, Boqing Gu, Ruslan Korets, Boris Gershman, Heidi J. Rayala, Zongwei Wang, Aria F. Olumi
This study shows that obesity-induced stem-like prostate remodeling reduces 5α-reductase inhibitor effectiveness in BPH, and combining weight control with therapy improves outcomes.
bioRxiv · Sep 8, 2025 · PreprintPathology