PathologybioRxivPreprint
Stem-like Prostate Remodeling in Obesity Mediates Resistance to 5α-Reductase Inhibition Therapy in BPH
Xingbo Long, Christina Sharkey, Rongbin Ge…·Aria F. Olumi
This study shows that obesity-induced stem-like prostate remodeling reduces 5α-reductase inhibitor effectiveness in BPH, and combining weight control with therapy improves outcomes.