Rapid depletion and super-resolution microscopy reveal an unexpected role of the nuclear-speckle protein SRSF5 in paraspeckle assembly and dynamics during cellular stress
Ellen Kazumi Okuda, Laurell F. Kessler, Benjamin Arnold, Ricarda J. Riegger, María Clara Hernández Cañás, Ewelina Żebrowska, Cem Bakisoglu, Mara Rudigier, Christine Krost, Helder Yudi Nagasse, Jan Keiten‐Schmitz, Stefan P Müller, David Staněk, Dorothee Dormann, Kathi Zarnack, , Michaela Müller-McNicoll
This study shows SRSF5 is critical for paraspeckle assembly and dynamics, with stress-induced changes and compensatory effects on TDP-43 and NEAT1.
Nucleic Acids Research · Jul 14, 2025Peer-reviewedCell Biology