David Staněk

Molecular mechanism of coilin interaction with core snRNPs

The paper identifies the molecular mechanism by which coilin distinguishes mature from immature snRNPs through its C-terminus containing an RNA-binding region and a Tudor-like domain that interacts with Sm proteins.

PRPF8-associated retinitis pigmentosa variant induces human neural retina-autonomous photoreceptor defects

This study shows that the PRPF8-Y2334N variant causes photoreceptor defects in human neural retina cells without affecting the retinal pigment epithelium.

Rapid depletion and super-resolution microscopy reveal an unexpected role of the nuclear-speckle protein SRSF5 in paraspeckle assembly and dynamics during cellular stress

This study shows SRSF5 is critical for paraspeckle assembly and dynamics, with stress-induced changes and compensatory effects on TDP-43 and NEAT1.

A novel SATB1 protein isoform with different biophysical properties

The paper identifies a novel SATB1 protein isoform with distinct biophysical properties and shows its role in T cell development and potential links to cancer.

Retinitis pigmentosa associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule neurons

This study shows that mutations in Prpf8 in mice lead to misexpression of circRNAs and cerebellar granule neuron degeneration.