Membrane transporter Progressive Ankylosis Protein Homolog (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageing.
Emma L. James, Muy‐Teck Teh, Yufeng Li, Christine Wagner-Bock, Zahra F. Al-Khateeb, Lee Peng Karen‐Ng, Terry Roberts, Linnea Synchyshyn, Amy L. Lewis, Ana O’Loghlen, Andrew R. Silver, Adina Teodora Michael-Titus, Mark H. Bennett, Jacob G. Bundy, Maria Elzbieta Mycielska, Eric Kenneth Parkinson
This study identifies ANKH/Ank as a novel regulator of senescence-derived extracellular citrate in humans and mice, showing its regulation by DNA damage, inflammation, and ageing.
Frontiers in Aging · Jun 4, 2025Peer-reviewedCell Biology