Author

Christine Worthington

University of Pittsburgh Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Randall E. BrandiD· 2 shared Aatur Dilip SinghiiD· 1 shared Anirban MaitraiD· 1 shared Anna E LokshiniD· 1 shared Ben StaaliD· 1 shared Brian B. HaabiD· 1 shared Camden LopeziD· 1 shared Daniel W. ChaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Randall E. BrandORCID

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2 papers

Recent·Most cited

High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis

Jongmin Jacob Woo, Zhenyu Sun, Yingwei Hu, Trung Hoàng, Christine Worthington, Katelyn Smith, Aatur Dilip Singhi, Randall E. Brand, Daniel W. Chan, Qing Kay Li, Ralph H. Hruban, Hui Zhang

This study develops a high-sensitivity spatial proteomics method, SP-Max, to analyze protein expression changes in pancreatic tissues from normal to cancerous states.

Analytical Chemistry · Feb 18, 2026Peer-reviewedCancer Biology

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

Brian B. Haab, Lu Qian, Ben Staal, Maneesh Jain, Johannes Francois Fahrmann, Christine Worthington, Denise Prosser, Liudmila Velokokhatnaya, Camden Lopez, Runlong Tang, Mark W. Hurd, Gopalakrishnan Natarajan, Sushil Kumar K, Lynette M. Smith, Samir Hanash, , Randall E. Brand

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

Cancer Letters · Sep 12, 2024Peer-reviewedCancer Biology