The paper identifies STK38 as a YAP1 kinase that regulates paligenosis by autophagy-dependent degradation, enabling differentiated cells to act as progenitors during tissue regeneration.

Proceedings of the National Academy of Sciences · Mar 30, 2026Peer-reviewedDevelopmental Biology

High-Sensitive Spatial Proteomics for Pancreatic Cancer Progression Analysis

Jongmin Jacob Woo, Zhenyu Sun, Yingwei Hu, Trung Hoàng, Christine Worthington, Katelyn Smith, Aatur Dilip Singhi, Randall E. Brand, Daniel W. Chan, Qing Kay Li, Ralph H. Hruban, Hui Zhang

This study develops a high-sensitivity spatial proteomics method, SP-Max, to analyze protein expression changes in pancreatic tissues from normal to cancerous states.

Analytical Chemistry · Feb 18, 2026Peer-reviewedCancer Biology

Elucidating the heterogeneity of immunotherapy response and immune-related toxicities by longitudinal ctDNA and immune cell compartment tracking in lung cancer

Joseph Christopher Murray, Lavanya Sivapalan, Karlijn Hummelink, Archana Balan, James Robert White, Noushin Niknafs, Lamia Rhymee, Gavin Pereira, Nisha Rao, Benny Weksler, Nathan Bahary, Jillian A. Phallen, Alessandro Leal, David L. Bartlett, Kristen Ashley Marrone, , Valsamo Anagnostou

This study tracks ctDNA and immune cell changes in lung cancer patients on immunotherapy to identify molecular responses and immune-related toxicities.

Clinical Cancer Research · Nov 8, 2023Peer-reviewedGenomics

Mapping In Vivo O-Glycoproteome Using Site-specific Extraction of O-linked glycopeptides (EXoO)

Weiming Yang, Minghui Ao, Yingwei Hu, Qing Kay Li, Hui Zhang

The paper introduces EXoO, a method for site-specific extraction of O-linked glycopeptides, enabling the mapping of over 3,000 O-linked glycosylation sites across human tissues and revealing significant differences between tumor and normal kidney tissues.

Molecular Systems Biology · Nov 1, 2018Peer-reviewedSystems Biology