The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced exacerbations in cigarette smoke-exposed mice
Magdiel Pérez-Cruz, Bachirou Koné, Rémi Porte, Christophe Carnoy, Julien Tabareau, Pierre Gosset, François Trottein, Jean-Claude Sirard, Muriel Pichavant, Philippe Gosset
This study shows that flagellin, a TLR5 agonist, reduces NTHi-induced COPD exacerbations in cigarette smoke-exposed mice by increasing IL-22 and β-defensin2 production.
bioRxiv · Jul 8, 2020Immunology