Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner
Rebecca M. Beiter, Hannah E. Ennerfelt, Courtney R. Rivet-Noor, Andrea R. Merchak, Robin Bai, David M. Johanson, Erica R. Slogar, Katia Sol‐Church, Jennifer L. Phillips, Tim Bathe, Christopher C. Overall, John R. Lukens, Stefan Prokop, Alban Gaultier
This study shows that clusterin, produced by oligodendrocyte progenitor cells (OPCs), inhibits their differentiation into oligodendrocytes and prevents myelin repair in Alzheimer's disease by reducing IL-9 production.
bioRxiv · Mar 6, 2020 · PreprintNeuroscience