Stefan Prokop

Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasis

This study shows that Syndecan-4 has both HS-dependent and HS-independent effects on Aβ amyloid homeostasis, reducing amyloid deposition in a mouse model.

PERK Deficiency Amplifies Molecular, Structural, and Network Vulnerability to Repetitive Mild Traumatic Brain Injury

This study shows that PERK deficiency worsens molecular, structural, and network damage in mice after repetitive mild traumatic brain injury.

Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation

This study examines how acetylation and phosphorylation mutations affect tau aggregation and seeding in Alzheimer's and PSP models.

Pathological α-Synuclein Perturbs Nuclear Integrity

This study shows pathological α-synuclein localizes in the nucleus, causing nuclear damage and dysfunction in synucleinopathy models and human tissue.

Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

Large- Scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity

The paper performs large-scale proteomic analysis of Alzheimer's disease brain regions across different racial and ethnic groups, identifying AD-related protein changes and APOE4 concordance with genotype.

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations

This paper presents a multi-omics dataset from multi-ethnic Alzheimer's disease brain donors, including transcriptome, genome, and proteome data, to improve precision medicine for underrepresented populations.

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease

The paper identifies a conserved Aβ amyloid 'responsome' in human and mouse AD brains, showing how amyloid scaffolds proteins involved in disease pathology.

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function

This study shows that targeted brain-specific tauopathy in mice leads to skeletal muscle weakness and altered gene expression.

Repetitive mild traumatic brain injury impairs resting state fMRI connectivity and alters protein profile signaling networks

This study investigates how repetitive mild traumatic brain injury (rmTBI) affects brain functional connectivity and protein profiles in mice, revealing altered connectivity and inflammatory responses.

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

This study shows that deletion of Abi3/Gngt2 affects amyloid β and tau pathologies differently with age in AD models.

Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner

This study shows that clusterin, produced by oligodendrocyte progenitor cells (OPCs), inhibits their differentiation into oligodendrocytes and prevents myelin repair in Alzheimer's disease by reducing IL-9 production.