Andrea R. Merchak

RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress

The paper investigates RGS10 levels in Parkinson's Disease (PD) patients and mice, finding reduced RGS10 in CSF and peripheral immune cells, and showing RGS10 deficiency exacerbates immune dysregulation in chronic systemic inflammation.

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

High-plex Digital Spatial Profiling Identifies Subregion-Dependent Directed Proteome Changes Across Multiple Variants of Dementia

This study uses spatial proteomics to identify subregion-dependent protein changes in dementia variants, revealing disease-specific patterns in cortical layers and white matter.

Lactobacillus maintains IFNγ homeostasis to promote behavioral stress resilience.

This study shows that Lactobacillus species maintain IFNγ homeostasis, promoting stress resilience in mice, and provides a model to study probiotic effects on behavior.

Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner

This study shows that clusterin, produced by oligodendrocyte progenitor cells (OPCs), inhibits their differentiation into oligodendrocytes and prevents myelin repair in Alzheimer's disease by reducing IL-9 production.