Intern-based thermoregulated meganucleases for biocontainment of genetic material
Gary W. Foo, Christopher D. Leichthammer, Ibrahim M. Saita, Nicholas D. Lukas, Izabela Z. Batko, David E. Heinrichs, David R. Edgell
The paper develops thermoregulated meganucleases to degrade DNA at 18°C, preventing the spread of engineered genetic material outside the mammalian gut.
bioRxiv · Aug 14, 2023 · PreprintSynthetic Biology