Author

Izabela Z. Batko

Western University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:variant calling· 1

Frequent Co-Authors

David E. HeinrichsiD· 2 shared David R. EdgelliD· 2 shared Gary W. FooiD· 2 shared Aathavan S. Uruthirapathy· 1 shared Christopher D. Leichthammer· 1 shared Claire Shuiqing ZhangiD· 1 shared Ibrahim M. Saita· 1 shared Nicholas D. Lukas· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersSynthetic Biology

David E. HeinrichsORCID

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2 papers

Recent·Most cited

Genetic entanglement enables ultra-stable biocontainment in the mammalian gut

Gary W. Foo, Aathavan S. Uruthirapathy, Claire Shuiqing Zhang, Izabela Z. Batko, David E. Heinrichs, David R. Edgell

The paper introduces STALEMATE, a biocontainment system that reduces genetic escape rates in engineered bacteria by entangling genetic sequences, achieving rates below 10^-10 in mice.

ACS Synthetic Biology · Sep 7, 2025Peer-reviewedSynthetic Biology

Intern-based thermoregulated meganucleases for biocontainment of genetic material

Gary W. Foo, Christopher D. Leichthammer, Ibrahim M. Saita, Nicholas D. Lukas, Izabela Z. Batko, David E. Heinrichs, David R. Edgell

The paper develops thermoregulated meganucleases to degrade DNA at 18°C, preventing the spread of engineered genetic material outside the mammalian gut.

bioRxiv · Aug 14, 2023 · PreprintSynthetic Biology