Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre-cancer lesions
Yupei Lin, Venugopala Reddy Mekala, Jianrong Li, Xuan Wang, Muhammad Aminu, Jia Wu, Jianjun J. Zhang, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng
This study develops gene expression signatures from LUSC tumors to predict progression risk of precancerous lesions, finding they outperform genomic aberrations in prognosis and correlate with immune features.
International Journal of Cancer · Dec 16, 2025Peer-reviewedBioinformatics