Yupei Lin

This study develops gene expression signatures from LUSC tumors to predict progression risk of precancerous lesions, finding they outperform genomic aberrations in prognosis and correlate with immune features.

This paper introduces QUAIL, a model for detecting genetic variants affecting trait variability, and finds 11 novel BMI vQTL with interactions with physical activity and sedentary behavior.

The paper identifies novel risk genes for autism spectrum disorder using transcriptome-wide transmission disequilibrium analysis across 7,805 ASD proband-parent trios.

This paper introduces PUMAS, a method to fine-tune polygenic risk scores using GWAS summary statistics, improving predictive performance and statistical power in downstream analyses.