TOXOPLASMA ACTIVATES HOST HYPOXIA INDUCIBLE FACTOR-1 BY CYTOPLASMIC TRAPPING AND LAMP1-DEPENDENT LYSOSOMAL DEGRADATION OF PROLYL-HYDROXYLASE 2
Celia Florimond, Tongi Liu, Matthew Menendez, Kerstin Lippl, Christopher J. Schofield, Ira J. Blader
This study shows Toxoplasma gondii activates HIF-1 by trapping and lysosomal degradation of PHD2, a host protein that normally inhibits HIF-1.
bioRxiv · Apr 7, 2018 · PreprintCell Biology