Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response
Kanishk Jain, Pata-Eting Kougnassoukou Tchara, Abid Ali Khan, Amanuel B. Mengistalem, Aidan P Holland, Christopher N Bowman, Matthew R. Marunde, Tiffany A. Engel, Irina K Popova, Spencer W Cooke, Krzysztof Krajewski, Michael‐Christopher Keogh, Jean‐Philippe Lambert, Brian D. Strahl
This study shows PHRF1's PHD finger binds histone H3 N-terminal region, regulates transcription and RNA splicing, and is essential for DNA damage response.
Nucleic Acids Research · Jul 8, 2025Peer-reviewedBiochemistry