Krzysztof Krajewski

Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes

This study shows that BRD4's tandem bromodomains cooperatively bind poly-acetylated nucleosomes, enhancing chromatin engagement and influencing breast cancer phenotypes.

Nucleosome context regulates chromatin reader preference

The paper investigates how nucleosome context influences chromatin reader binding preferences using biochemical and genomic approaches, revealing that multivalent engagement often has regulatory effects beyond simple additivity.

Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response

This study shows PHRF1's PHD finger binds histone H3 N-terminal region, regulates transcription and RNA splicing, and is essential for DNA damage response.

Dual roles of histone H3 lysine-4 in antagonizing Polycomb group function and promoting target gene expression

The paper shows that H3.2K4 antagonizes Polycomb group activity and promotes target gene expression in vivo.

Nucleosome conformation dictates the histone code

The paper shows that histone reader domains interact with PTMs in a nucleosome-dependent manner, necessitating a refinement of the histone code concept to the nucleosome level.