Jean‐Philippe Lambert

The paper uses long-read RNA sequencing to identify non-coding isoform switching that regulates cell fate during reprogramming.

This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.

This study investigates how NuA4/TIP60 complex acetylates and loads H2A.Z onto chromatin to regulate transcription, showing that acetylation precedes chromatin incorporation at promoters.

This study shows PHRF1's PHD finger binds histone H3 N-terminal region, regulates transcription and RNA splicing, and is essential for DNA damage response.

This paper introduces UltraID-LIPA, a platform combining optogenetic-induced protein aggregation and proximity biotinylation to identify α-synuclein-interacting proteins, revealing endolysosomal proteins' role in early aggregation.

The paper develops and applies CasTurbo and CasUltra to profile locus-specific chromatin proteomes and study BET inhibitor effects on MYC promoter dynamics.

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

This study shows that the transcription factor MITF interacts with the MRN complex to modulate the DNA damage response in melanoma, contributing to cancer predisposition.

The paper identifies and characterizes multiple protein complexes associated with MRG15 and MRGX, revealing their roles in chromatin modification and transcription regulation.

The paper identifies RebL1 as an orthologue of human RBBP4/7 in Tetrahymena thermophila, showing its role in epigenetic regulation and oncogenic functions across species.

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

This study identifies novel effector proteins of EPH receptors and shows they regulate cell polarity and morphogenesis through PAR-3 and CSK signaling.

The paper shows that SH3 domain specificity in PPIs is influenced by host protein identity and domain position, not just intrinsic domain properties.