Functional Genomics in Human iPSC-Derived Sinoatrial Node Cells Reveals Shared Regulatory Determinants of Heart Rate and Atrial Fibrillation
James Douglas Engel, Xianglong Zhang, Rajiv A. Mohan, Navraj Lally, Amanda W. Soe, Grace Yang, Daniel Lu, Olaia F. Vila, Vanessa Arias, Jasper Lee, Christophero Hale, Yi‐Hsiang Hsu, Chi-Ming Li, Gabriel B. Loeb, Arun Padmanabhan, , Vasanth Vedantham
The paper develops a human iPSC-derived sinoatrial node system to study heart rhythm-associated SNPs and identifies causal variants linked to heart rate and atrial fibrillation.
bioRxiv · Jul 1, 2023 · PreprintGenomics