Daniel Lu

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

This paper links CAD GWAS variants to causal genes in SMCs using single-cell chromatin accessibility and Hi-C data, creating a scV2E2G map for disease mechanism discovery.

The paper identifies causal genes in heart disease GWAS loci by integrating Hi-C, chromatin accessibility, and transcriptomic data, revealing regulatory relationships in cardiac fibroblasts.

The paper develops a human iPSC-derived sinoatrial node system to study heart rhythm-associated SNPs and identifies causal variants linked to heart rate and atrial fibrillation.

This paper describes a method to efficiently generate definitive hemogenic endothelium from human pluripotent stem cells, which can differentiate into hematopoietic progenitors and stem cells with multilineage potential.

The paper identifies RAB18 as a key regulator that enhances GalNAc-conjugated siRNA efficacy in Hep3B cells by improving siRNA delivery and RISC access.

The paper profiles small RNA expression in LPS-stimulated human monocytes and identifies a limited set of miRNAs upregulated during inflammation.