Author

Jasper Lee

Rockefeller University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genomics· 5

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:clustering· 2

Frequent Co-Authors

Andras Sziraki· 4 shared Junyue CaoiD· 4 shared Wei You ZhouiD· 4 shared Ziyu LuiD· 3 shared Abdulraouf AbdulraoufiD· 2 shared Chloe SchaeferiD· 2 shared Peter T. NelsoniD· 2 shared Sonya Anderson· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Andras Sziraki

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5 papers

Recent·Most cited

A Panoramic View of Cell Population Dynamics in Mammalian Aging

Zehao Zhang, Chloe Schaefer, Weirong Jiang, Ziyu Lu, Jasper Lee, Andras Sziraki, Abdulraouf Abdulraouf, Brittney D Wick, Maximilian Haeussler, Zhuoyan Li, Gesmira Molla, Rahul Satija, Wei You Zhou, Junyue Cao

PanSci, a single-cell transcriptome atlas of over 20 million cells throughout the mouse lifespan, unveils the temporal architecture of aging-associated cellular population dynamics, organ-specific immune cell shifts, and the lymphocytes role in organismal aging.

Science · Nov 28, 2024Peer-reviewedGenomics

A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brains

Andras Sziraki, Ziyu Lu, Jasper Lee, Gábor Bányai, Sonya Anderson, Abdulraouf Abdulraouf, Eli Metzner, Andrew Shuh-Huei Liao, Jason R. Banfelder, Alexander E. Epstein, Chloe Schaefer, Zihan Xu, Zehao Zhang, Li Gan, Peter T. Nelson, , Junyue Cao

The paper develops a high-throughput single-cell genomics approach to study age-related and Alzheimer's disease-associated cell population dynamics and molecular signatures in human and mouse brains.

Nature Genetics · Nov 30, 2023Peer-reviewedGenomics

Functional Genomics in Human iPSC-Derived Sinoatrial Node Cells Reveals Shared Regulatory Determinants of Heart Rate and Atrial Fibrillation

James Douglas Engel, Xianglong Zhang, Rajiv A. Mohan, Navraj Lally, Amanda W. Soe, Grace Yang, Daniel Lu, Olaia F. Vila, Vanessa Arias, Jasper Lee, Christophero Hale, Yi‐Hsiang Hsu, Chi-Ming Li, Gabriel B. Loeb, Arun Padmanabhan, , Vasanth Vedantham

The paper develops a human iPSC-derived sinoatrial node system to study heart rhythm-associated SNPs and identifies causal variants linked to heart rate and atrial fibrillation.

bioRxiv · Jul 1, 2023 · PreprintGenomics

PerturbSci-Kinetics: Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens

Zihan Xu, Andras Sziraki, Jasper Lee, Wei You Zhou, Junyue Cao

PerturbSci-Kinetics enables analysis of transcriptome kinetics through single-cell RNA profiling of CRISPR screens, revealing key regulators in miRNA and mitochondrial RNA processing.

bioRxiv · Jan 29, 2023 · PreprintGenomics

A comprehensive view of cell-type-specific temporal dynamics in human and mouse brains

Ziyu Lu, Melissa Zhang, Jasper Lee, Andras Sziraki, Sonya Anderson, Shaoyu Ge, Peter T. Nelson, Wei You Zhou, Junyue Cao

This paper introduces TrackerSci, a technique to profile progenitor cells in mouse and human brains, revealing cell-type-specific dynamics and aging-related changes.

bioRxiv · Oct 1, 2022 · PreprintGenomics