Drug discovery to counteract antinociceptive tolerance with mu-opioid receptor endocytosis
Po‐Kuan Chao, Yi‐Yu Ke, Hsiao-Fu Chang, Yihan Huang, Li-Chin Ou, Jian‐Ying Chuang, Yen‐Chang Lin, Pin-Tse Lee, Wan‐Ting Chang, Shuchun Chen, Shau‐Hua Ueng, John Tsu‐An Hsu, Pao‐Luh Tao, Ping‐Yee Law, Horace H. Loh, , Shiu-Hwa Yeh
This study identifies cardiotonic steroids as positive allosteric modulators of MOR that enhance morphine-induced endocytosis and reduce tolerance in pain models.
bioRxiv · Aug 29, 2017 · PreprintNeuroscience