NeurosciencebioRxivPreprint
Drug discovery to counteract antinociceptive tolerance with mu-opioid receptor endocytosis
Po‐Kuan Chao, Yi‐Yu Ke, Hsiao-Fu Chang…·Shiu-Hwa Yeh
This study identifies cardiotonic steroids as positive allosteric modulators of MOR that enhance morphine-induced endocytosis and reduce tolerance in pain models.
DOI 10.1101/182360