Author

Chuanlong Zeng

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:transformer / foundation model· 2 Approach:benchmark study· 1 Assay:metabolomics· 1 Research Focus:perturbation response prediction· 1 Assay:protein structure· 1

Frequent Co-Authors

Mingyue ZhengiD· 3 shared Duanhua CaoiD· 2 shared Jiacheng XiongiD· 2 shared Yuqi ShiiD· 2 shared Dan TengiD· 1 shared Jie YuiD· 1 shared Jingxin Rao· 1 shared Mingan CheniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBioinformatics

Mingyue ZhengORCID

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3 papers

Recent·Most cited

MetaReact: A Reaction-Aware Transformer for End-to-End Prediction of Drug Metabolism

Yitian Wang, Jingxin Rao, Wei Zhang, Yuqi Shi, Chuanlong Zeng, Rongrong Cui, Yinquan Wang, Jiacheng Xiong, Xutong Li, Mingyue Zheng

MetaReact predicts drug metabolites and enzyme selectivity using a reaction-aware Transformer, outperforming existing methods in accuracy and generalizability.

bioRxiv · Mar 18, 2026 · PreprintBiochemistry

Benchmarking Real-World Applicability of Molecular Generative Models from De novo Design to Lead Optimization with MolGenBench

Duanhua Cao, Zhehuan Fan, Jie Yu, Mingan Chen, Xinyu Jiang, Xia Sheng, Xingyou Wang, Chuanlong Zeng, Xiaomin Luo, Dan Teng, Mingyue Zheng

This paper introduces MolGenBench, a benchmark for evaluating molecular generative models in drug discovery, highlighting gaps between current models and real-world pharmaceutical workflows.

bioRxiv · Nov 3, 2025 · PreprintBioinformatics

Bridging 3D Molecular Structures and Artificial Intelligence by a Conformation Description Language

Jiacheng Xiong, Yuqi Shi, Wei Zhang, Runze Zhang, Zhiyi Chen, Chuanlong Zeng, Xun Jiang, Duanhua Cao, Zhaoping Xiong, Mingyue Zheng

The paper introduces ConfSeq, a conformation description language for 3D molecular structures, enabling sequence-based modeling and achieving state-of-the-art results in 3D molecular tasks.

bioRxiv · May 7, 2025 · PreprintBioinformatics