Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism.
Pavel Stupakov, Golbahar Sadatrezaei, Ines Velazquez Quesada, Lillian A. Boe, Chun-Hao Chen, Francesca Gaino, Efsevia Vakiani, İhsan Ekin Demir, Boris Reva, Bojana Gligorijevic, Richard J. Wong, Sylvie Deborde
This study identifies a mechanism by which pancreatic fibrosis activates protumorigenic Schwann cells through nuclear mechanosensing involving c-Jun phosphorylation and Phospholipase A2.
Gut · Jun 23, 2026Peer-reviewedCancer Biology