Author

Sylvie Deborde

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-6630-4029Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:mixed model· 1

Frequent Co-Authors

Pavel StupakoviD· 2 shared Richard J. WongiD· 2 shared Bojana GligorijeviciD· 1 shared Boris RevaiD· 1 shared Christina S. LeslieiD· 1 shared Chun-Hao Chen· 1 shared Dig Vijay Kumar YarlagaddaiD· 1 shared Efsevia VakianiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Pavel StupakovORCID

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2 papers

Recent·Most cited

Invasion status stratifies the composition of the human pancreatic cancer perineural niche

Zainab Hussain, Dig Vijay Kumar Yarlagadda, Qianzi Li, Nuray Tezcan, Pavel Stupakov, Golabahar Sadatrezaei, Richard J. Wong, Joan Massagué, Zeynep Cagla Tarcan, Olca Baştürk, Sylvie Deborde, Christina S. Leslie, Mara H. Sherman

Xenium and single-nucleus profiling of 14 human pancreatic tumors shows invaded nerve neighborhoods enriched for classical cancer cells, myCAFs and lipid-handling macrophages but depleted of lymphocytes.

bioRxiv · Aug 6, 2026 · PreprintCancer Biology✦ In-depth digest

Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism.

Pavel Stupakov, Golbahar Sadatrezaei, Ines Velazquez Quesada, Lillian A. Boe, Chun-Hao Chen, Francesca Gaino, Efsevia Vakiani, İhsan Ekin Demir, Boris Reva, Bojana Gligorijevic, Richard J. Wong, Sylvie Deborde

This study identifies a mechanism by which pancreatic fibrosis activates protumorigenic Schwann cells through nuclear mechanosensing involving c-Jun phosphorylation and Phospholipase A2.

Gut · Jun 23, 2026Peer-reviewedCancer Biology