PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
Ronak Lakhia, Harini Ramalingam, Chun-Mien Chang, Patricia Cobo-Stark, Laurence Michael Biggers, Andrea Flaten, Jesus Alvarez, Tania Valencia, Darren P. Wallace, Edmund Chun Yu Lee, Vishal Patel
This study identifies cis-inhibition of PKD1 and PKD2 mRNAs via miR-17 in ADPKD and shows that disrupting this mechanism reduces cyst growth in multiple models.
Nature Communications · Aug 14, 2022Peer-reviewedGenetics