TMEM100 attenuates NF-κB activation via disrupting the PRDX1-GNAI2 complex to alleviate acute lung injury
Cheng Qian, Linxin Pan, Chuncan Si, Youwen Du, Jingying Wang, Yue Jing He, Bingjie Liu, Sa Xiao, Yufeng Zhu, Fengsong Wang, Kezhen Wang
This study shows TMEM100 reduces NF-κB activation by breaking the PRDX1-GNAI2 complex, thereby alleviating acute lung injury in mice.
bioRxiv · Oct 24, 2025 · PreprintImmunology