A humanized 16A antibody conjugated with DNA topoisomerase I inhibitors, targeting a GSTA glycosite-signature epitope.
Yu He, Zhaohui Ji, Wang Nian, Jingxia Wang, Chenxi Zhu, Chunchao Feng, Xiaoding Tan, Dapeng Zhou
This paper evaluates the antitumor efficacy of humanized 16A antibody conjugates with DNA topoisomerase I inhibitors, showing potent in vitro and in vivo activity against MUC1-expressing tumors.
bioRxiv · Mar 22, 2025 · PreprintPharmacology & Toxicology