Author

Chunhan Zhang

Barnard College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

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Brian J. LeeiD· 1 shared Isaac DumouliniD· 1 shared Shan ZhaiD· 1 shared Xiaohui S. LiniD· 1 shared Yuxuan WangiD· 1 shared

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2026-2026 · peak 1/yr

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Brian J. LeeORCID

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1 paper

Recent·Most cited

PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its partners, into nuclear condensates to elicit cytotoxicity

Isaac Dumoulin, Brian J. Lee, Chunhan Zhang, Xiaohui S. Lin, Yuxuan Wang, Shan Zha

The paper shows PARG inhibition causes nuclear condensates that sequester PAR-binding repair proteins, leading to cytotoxicity and identifying PAR-binding factor loss as potential biomarkers for PARG-targeted therapy.

bioRxiv · Mar 20, 2026 · PreprintMolecular Biology