PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its partners, into nuclear condensates to elicit cytotoxicity
Isaac Dumoulin, Brian J. Lee, Chunhan Zhang, Xiaohui S. Lin, Yuxuan Wang, Shan Zha
The paper shows PARG inhibition causes nuclear condensates that sequester PAR-binding repair proteins, leading to cytotoxicity and identifying PAR-binding factor loss as potential biomarkers for PARG-targeted therapy.
bioRxiv · Mar 20, 2026 · PreprintMolecular Biology