Author

Xiaohui S. Lin

Columbia UniversityORCID 0000-0003-1747-1485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Brian J. LeeiD· 2 shared Shan ZhaiD· 2 shared Alan E. TomkinsoniD· 1 shared Chunhan Zhang· 1 shared Isaac DumouliniD· 1 shared Kaitlynn F. Wolfe· 1 shared Kay Sze Karina Leung· 1 shared Nicolas Call· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Brian J. LeeORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 20, 2026

PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its partners, into nuclear condensates to elicit cytotoxicity

Isaac Dumoulin, Brian J. Lee, Chunhan Zhang…·Shan Zha

The paper shows PARG inhibition causes nuclear condensates that sequester PAR-binding repair proteins, leading to cytotoxicity and identifying PAR-binding factor loss as potential biomarkers for PARG-targeted therapy.

1 citation

experimental assay

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Cell BiologyNucleic Acids ResearchPeer-reviewedFeb 8, 2025

XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites

Xiaohui S. Lin, Kay Sze Karina Leung, Kaitlynn F. Wolfe…·Shan Zha

This study shows that XRCC1 facilitates PARP1-mediated recruitment of PARP2 to DNA damage sites through PAR binding and interaction with PARP2.

22 citationstop 3%

humanDNA methylation

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