ZMS-6659, a selective Polθ helicase inhibitor, demonstrates anti-tumor activity as monotherapy and synergy effect with PARP inhibitors and topoisomerase inhibitors
Lei Jiang, Jiajia Li, Lu Liu, Mengying Li, Wenjing Li, Zhen Li, Shuo Qian, Mingyue Shi, Jing Dai, Chunxia Ao, Ying Qu, Zhengtao Li, Li Zhou, Yang Chen, Xiyuan Wang, , Liting Xue
ZMS-6659, a Polθ helicase inhibitor, shows anti-tumor activity as monotherapy and synergizes with PARP inhibitors and topoisomerase inhibitors in HR-deficient and HR-proficient models.
bioRxiv · Apr 19, 2025 · PreprintCancer Biology