Author

Chunxia Zhao

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Andrew BlauveltiD· 1 shared Christopher G. BunickiD· 1 shared James R. FulleriD· 1 shared Julie Macoin· 1 shared Nikolaos BirisiD· 1 shared Raj ChovatiyaiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperPharmacology & Toxicology

Andrew BlauveltORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintSep 16, 2025

A Dual-Action Mechanism to Prevent OX40 Signaling: The Structural Basis for the Differentiated Antagonist STAR-0310

Nikolaos Biris, Chunxia Zhao, Julie Macoin…·Christopher G. Bunick

This paper describes the structural basis of STAR-0310, a novel anti-OX40 antibody, which prevents OX40 signaling through a dual mechanism of blocking receptor trimerization and disrupting pre-formed complexes, showing greater efficiency than comparator antibodies.

DOI 10.1101/2025.09.16.676329

humanexperimental assay

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