A structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia
Luke Jones, Oleksii S. Rukhlenko, Tânia Dias, Hiroaki Imoto, Ciardha Carmody, Kieran J. Wynne, Boris Ν. Kholodenko, Jonathan Bond
This paper uses a structure-based model to identify synergistic RAF inhibitor combinations effective against RAS-mutant AML in vitro and in vivo.
bioRxiv · Apr 29, 2025 · PreprintCancer Biology