Boris Ν. Kholodenko

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

This study identifies how IFN and mimetics prevent TB susceptibility by modulating iron metabolism and lipid peroxidation in macrophages.

This paper uses a structure-based model to identify synergistic RAF inhibitor combinations effective against RAS-mutant AML in vitro and in vivo.

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

The paper identifies a causal network controlling endothelial cell states in critical limb ischemia using transcriptomics data and cSTAR analysis.

This study shows VEGF inhibits arterial specification in capillaries by suppressing Sox17, preventing premature arterialization driven by shear stress.

The paper shows how periodic GTPase waves coordinate leading and trailing edge dynamics during cell migration through RhoA-Rac1 interactions.

This study identifies transcriptional regulatory mechanisms in mouse lung tissue exposed to carbon nanotubes using gene regulatory network analysis.