Kieran J. Wynne

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

The paper examines how proteolysis in seeds is influenced by germination, homogenisation, and species mixture, finding increased proteolytic activity and peptide release.

This study shows MYCN inhibits TrkC-induced differentiation in neuroblastoma by disrupting PKA signaling, with implications for targeting PKA to treat high-risk cases.

This study shows SS18-SSX sustains oncogenic transcription without needing SWI/SNF activity, identifies P300 as a critical co-factor, and demonstrates targeting P300 or SWI/SNF as therapeutic strategies.

This study identifies a synergistic combination of DPI and MitoQ that targets mitochondrial metabolism in MYCN-amplified neuroblastoma cells, enhancing chemotherapeutic efficacy.

The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.

This paper uses a structure-based model to identify synergistic RAF inhibitor combinations effective against RAS-mutant AML in vitro and in vivo.

This study identifies diphenyleneiodonium chloride as a compound that targets MYCN-amplified neuroblastoma by inducing proteasomal degradation of MYCN and reversing mitochondrial alterations.

The paper shows that gene loss in cancer is often compensated by paralog protein abundance changes, stabilizing protein-protein interaction networks and creating therapeutic vulnerabilities.

The paper identifies context-specific KRAS-effectors in Caco-2 cells and shows that culture contexts have a larger impact on interaction rewiring than genetic contexts.