Epigenetic Reactivation of CNS Endothelial Developmental Programs Triggers Adult Brain Angiogenesis, Promotes Post-Stroke Revascularization and Neuronal Regeneration.
Sithara Thomas, Cikesh Chandran, Lalit Kishore Ahirwar, Arif O. Harmanci, Chathathayil Mohammedali Shafeeque, Nabil J. Alkayed, Ari Dienel, Spiros Blackburn, Devin William McBride, Peeyush Kumar Thankamani Pandit
This study shows that deleting Hdac2 in adult CNS endothelial cells reactivates pro-angiogenic programs, promoting revascularization and neuronal regeneration after stroke.
bioRxiv · Aug 15, 2025 · PreprintNeuroscience