Nabil J. Alkayed

APOE4 genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice

This study investigates how APOE4 genotype and old age interact to affect cerebrovascular function, brain volume, and neuroinflammation in mice, finding that the interaction impacts these outcomes while age alone affects cognitive function and arterial stiffness.

Cerebral blood flow in elastin haploinsufficient and 3xTg-AD mice

This study examines cerebral blood flow and reactivity in elastin haploinsufficient and 3xTg-AD mice, finding impaired cerebrovascular reactivity in combined genotypes.

Epigenetic Reactivation of CNS Endothelial Developmental Programs Triggers Adult Brain Angiogenesis, Promotes Post-Stroke Revascularization and Neuronal Regeneration.

This study shows that deleting Hdac2 in adult CNS endothelial cells reactivates pro-angiogenic programs, promoting revascularization and neuronal regeneration after stroke.

APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.

GPR39 Localization in Aging Human Brain and Correlation of Expression and Polymorphism with Vascular Cognitive Impairment

The paper examines GPR39 localization in aged human brains and correlates its expression and polymorphism with vascular cognitive impairment.

Bidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR

The paper identifies GPR39 as a microvascular smooth muscle cell receptor regulated by opposing eicosanoids, 15-HETE and 14,15-EET, which modulate coronary vascular resistance through distinct mechanisms.