Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos
Elena Lo Furno, Isabelle Busseau, Antoine Aze, Claudio Lorenzi, Cima Saghira, Matt Christopher Danzi, Stephan L. Zuchner, Domenico Maiorano
The paper investigates mutagenesis in early embryos of Xenopus and Drosophila, showing that translesion DNA synthesis (TLS) driven by Rad18 contributes to high mutation rates.
Nucleic Acids Research · Dec 22, 2021Peer-reviewedDevelopmental Biology