Claudio Lorenzi

An integrated, transcript-resolution atlas of prostate cancer progression unmasks associations with oncogenic pathways

A transcript-resolution prostate cancer atlas, built by uniformly reprocessing public RNA-seq cohorts, links isoform switches in cancer genes to oncogenic pathway activity and some to CRPC survival.

Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output Program in Prostate Cancer

This study shows that disrupting FOXA1 and FOXA2 disrupts oncogenic programs in both AR-positive and AR-negative prostate cancers.

Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos

The paper investigates mutagenesis in early embryos of Xenopus and Drosophila, showing that translesion DNA synthesis (TLS) driven by Rad18 contributes to high mutation rates.

NF90 Modulates Processing of a Subset of Human Pri-miRNAs

The paper shows NF90 modulates processing of a subset of human pri-miRNAs by binding to stable intronic structures, increasing mature miRNA abundance when NF90 is lost.

PickPocket : Pocket binding prediction for specific ligands family using neural networks.

PickPocket predicts ligand-binding pockets for specific ligand families using neural networks, achieving >90% accuracy on fatty acid-like ligands with manually curated data.