CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolism.
Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai, Margaret Ashcroft
This study shows CHCHD4 promotes tumour cell proliferation and suppresses EMT through complex I-mediated mitochondrial metabolism.
bioRxiv · Jan 7, 2019 · PreprintCell Biology