Recapitulating the notochord to nucleus pulposus transition from human mesendoderm progenitors in 3D
Julie Warin, Nicolas Védrenne, Bluwen Guidoux-D’halluin, Claire Chédeville, Maelle Blanche, Clemence Maillard, Caroline Chariau, Christabel Thembela Dube, Romain Desprat, Benjamin Gantenbein, Stephen M. Richardson, Jérôme Guicheux, Laurent David, Marianna A. Tryfonidou, Jean-Marc Lemaı̂tre, Anne Camus
This study develops a 3D model to recapitulate the transition from human mesendoderm progenitors to nucleus pulposus-like cells using single-cell transcriptomics and spatial profiling.
bioRxiv · Oct 6, 2026 · PreprintCell Biology