Jean-Marc Lemaı̂tre

Recapitulating the notochord to nucleus pulposus transition from human mesendoderm progenitors in 3D

This study develops a 3D model to recapitulate the transition from human mesendoderm progenitors to nucleus pulposus-like cells using single-cell transcriptomics and spatial profiling.

Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress

This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.

A Novel Blood-Based Epigenetic Clock for Intrinsic Capacity Predicts Mortality and is Associated with Clinical, Immunological and Lifestyle Factors

The paper develops a DNA methylation-based epigenetic clock to predict mortality and associate with clinical, immunological, and lifestyle factors related to intrinsic capacity.

A single short reprogramming early in life improves fitness and increase lifespan in old age

A single short reprogramming early in life rejuvenates cell physiology, improves body composition, tissue fitness and increases lifespan in elderly.

Detailed analysis of public RNAseq data and longnon-coding RNA: a proposed enhancement to mesenchymalstem cell characterisation

The paper analyzes public RNAseq data to identify lncRNAs specific to mesenchymal stem cells and proposes them as potential cell markers.