Gene-corrected Parkinson's disease neurons show the A30P alpha-synuclein point mutation leads to reduced neuronal branching and function
Peter A. Barbuti, Bruno F. R. Santos, Paul M. A. Antony, François Massart, Gérald Cruciani, Claire Dording, Lukas Pavelka, Yong‐Jun Kwon, Rejko Krüger
This study shows that the A30P alpha-synuclein mutation in Parkinson's disease neurons reduces branching and function, with mitochondrial dysfunction and susceptibility to Rotenone.
bioRxiv · Nov 5, 2020 · PreprintNeuroscience